On 1/1/47 (per Virginia Hwy Bulletin), US 460 was extended west to Kentucky, replacing:

VA 24 and VA 117 from Roanoke to Salem
A duplex with US 11 from Salem to Christiansburg
VA 8 from Christiansburg to Pearisburg
VA 100 from Pearisburg to Rich Creek
A duplex with US 219 from Rich Creek to West Virginia
A duplex with US 19 from Bluefield to Claypool Hill.
VA 4 from Claypool Hill to Kentucky

Here is a more detailed look at the history of US 460 from a geographic standpoint.

Kentucky to Bluefield
When it appeared in 1947 replacing VA 4, US 460 essentially followed today's 460 from Kentucky to Grundy. It then followed what was the WB US 460 lanes through central Grundy, then current US 460 into Tazewell County. Near Raven, US 460 cut south on SR 7xx to Raven, then VA 67 east.
US 460 followed today's US 460, then US 460 Business through Richlands and Cedar Bluff before picking mainline 460 back up to Claypool Hill. US 460 then followed US 19-460 east to Tazewell except it used SR 637 through Pounding Mill.
US 460 followed US 19-460 Business through Tazewell, then followed the routing of US 19 all the way to its West Virginia crossing at Bluefield.

VA 4 Kentucky to Claypool Hill 1944 Official

US 460 replaces VA 4 1947 Official

Adjustments: About 1960, US 19-460 was taken off SR 637 in the Pounding Mill area.
In 196x, US 460 was placed on one-way alignments at Grundy. WB used the original routing. EB was placed on the road that had been assigned as US 460 ALT, running behind the town.
In 1970, US 460 was placed on a new alignment bypassing Raven, leaving behind VA 67 and SR 7xx.
In 1973, US 460 was placed on a freeway bypass of Richlands and Cedar Bluff, leaving behind US 460 Business.
Between 1962-75, US 460 was rerouted in Bluefield to a less direct route across Bluefield. It left Graham Ave at Walnut, then south to what is now Virginia Ave then east back out of town. Originally it had used Graham Ave all the way through.

US 19-460 straight through 1958 Tazewell County

US 19-460 zig-zags 1975 Tazewell County

In 1975, US 19-460 was placed on a freeway bypass north of Tazewell, leaving behind US 19-460 Business. In 1979, US 460 was removed from US 19 through Bluefield. At that time, a new expressway was constructed from the eastern SR 720 jct east to the West Virginia line. SR 720 west to US 19-460 was signed as TEMP US 460. In 1987, US 460 TEMP was removed from SR 720 as the rest of the expressway was opened.

US 460 bypasses Bluefield 1982 Official

In late 2013, US 460 was placed on a new bypass of the business district along Riverside Dr in the SR 615 Levisa Rd area between Van sant and Grundy. The old route became US 460 Business.
In the far future it is planned for US 460 to be put on new alignment west of the Grundy area to reach Kentucky in the vicinity of Breaks Interstate Park.

West Virginia to Christiansburg US 460 followed SR 1306 out of Glen Lyn, which no longer connects to SR 806 leading into Rich Creek. US 460 followed Main St through town, then used US 460 towards Pearisburg. After crossing the New River, US 460 followed VA 100 south to US 460 Business which it followed through Pearisburg. On the east side of town US 460 likely used SR 807.
US 460 continued on SR 636 to Ripplemead and crossed the New River just north of the current crossing. US 460 picked back up mainline 460, then used SR 1404 through Pembroke. US 460 used pieces of modern 460 but used SR 771 in Hoges Chapel; SRs 777 and 778 at Sinking Creek and SR 783 in Maybrook.
US 460 used SR 798, then a bit of VA 42, then SR 79x through Newport. Crossing Walker Mountain, US 460 used several abandoned alignments, plus SR 777. US 460 then used US 460 Business through Blacksburg, Merrimac and into Christiansburg.

mostly VA 8 West Virginia to Christiansburg 1944 Official

US 460 replaces VA 8 1947 Official

There, it picked up US 11 north leaving Christiansburg. It followed US 11 to Salem except it initially used SR 753 through Shawville; SR 745 and SR 603 (no longer continuous) through Elliston; SRs 813/821 at the Roanoke/Mongomery Line; SR 796 at Dixie Caverns.
In Salem US 460 used its current route to VA 116, then used Melrose Av, 11th St and Gilmer Ave east to US 11-220 Commonwealth Ave.
Adjustments: In 1948, US 11-460 was given a new alignment at Dixie Caverns, leaving behind SR 796.
In 1950, US 460 was given its current Salem to Roanoke routing.

US 460 early Roanoke route 1947 Official

US 460 current Roanoke route 1950 Official

Also in 1950, US 11-460 was placed on a bypass of Elliston leaving behind SR 745.
Also in 1950, US 11-460 was built on new alignment bypassing Stones Keep Rd and Wayside Rd, SRs 813 and 821 (discontinuous now)
In 1952, US 11-460 was given its bypass of Shawsville leaving behind SR 753.
In 1958, US 460 was placed on a new bypass of Pembroke, leaving behind SR 1404.
In 1961, US 460 was removed from SRs 777 and 778 in the Sinking Creek area.
In 1969, US 460 was placed on a freeway bypass of Christiansburg, leaving behind US 460 Business.
In 1974, US 460 was placed on its freeway bypass of Ripplemead. This left behind SR 636 and probably SR 807.
In Dec 1975 (CTB), US 460 was removed from Main St in Rich Creek, leaving behind SR 806.
In 1981, US 460 was placed on its freeway bypass of Pearisburg. This left behind VA 100 and US 460 Business.
In 1997, US 11-460 was removed from today's discontinuous SR 603 east of Elliston. From the early 50s to 1997, US 11-460 was split into a wide alignment using SR 603 for the NB routing.
About 2001, US 460 was extended south from the Christiansburg Bypass directly to I-81. Then US 460 was moved to the C/D lanes in each direction of I-81 at the Exit 118 complex. US 460 then continued to follow US 11 southeast of I-81. The old route along US 11 between these locations became more of US 460 Business.
About 2003, US 460 was placed on new freeway connecting the Blacksburg and Christianburg bypasses, leaving behind a long US 460 Business.

Roanoke to Lynchburg:
US 460 in 1933 followed its current route east out of Roanoke, then at Bonsack it veered onto Bonsack Rd, then back to 221-460. At Webster, US 460 used SR 738 on its way to Blue Ridge. US 460 picked back up US 221-460 through Villamont and Montvale. After more US 221-460, US 460 used SR 831 through Thaxton. US 460 then used US 221-460 and US 221 Bus to Bedford.
US 460 used US 221 Business and US 221 out of Bedford over to Forest, except it used SR 646 in the Norwood area. US 460 then headed briefly north on US 501 to Old Forest Rd (old VA 291) which US 460 used to approach Lynchburg.
Adjustments: In 1940, US 460 was placed on its current routing at Webster, leaving behind SR 738.
In 1956, US 460 was placed on its current Thaxton Bypass leaving behind SR 831.
US 460 (or US 221) was removed from SR 646 in Norwood sometime after 1958.
In 1965, US 460 was removed from Bonsack Rd onto its current alignment.
In December 1970 (CTB), US 460 was rerouted at Bedford onto its current Bedford Bypass and its route over to the Lynchburg Bypass. This was a replacement of VA 297. The old route became an extended US 221.

US 460 Bedford to Lynchburg (1933-70) 1970 Official

US 460 Bedford to Lynchburg (since 1970) 1972 Official

Lynchburg:
Initially, US 460 used Old Forest Rd to US 221 south to today's US 501 Business then headed south on Campbell Ave across the Lynchburg Expwy to today's US 460-501 Business. US 460 then headed out to current US 460 and out of Lynchburg.
In Oct 1935, US 460 was rerouted just west of Lynchburg to use today's US 221 Lakeside Dr. Old Forest Rd became VA 291 (unnumbered today).

US 460 on Old Forest Rd 1933 Official

US 460 on Lakeside Dr 1936 Official

US 460 removed from Campbell 1970 Official

In Feb 1969 (CTB), US 460 was rerouted to follow Fort/12th past Campbell Ave to follow today's US 221 routing. Maps show a one-way split alignment between 12th and today's US 29 Bus, most like involving Buchanan St and either 14th or 15th.
As described above, In Dec 1970 US 460 was removed from today's US 221 routing. Approaching Lynchburg US 460 followed today's US 460 Bus Timberlake Ave to US 501 Lynchburg Expressway, then US 460 followed this north to current US 221-460 Bus-501 Bus, which is where US 460 used to come out. This too was a replacement of VA 297 and also a duplex with then-US 29.
In 1975, US 460 was placed on a new expressway from then-US 29 east to Candler Mtn, then northeast on more new freeway to meet back up with US 460-501. The old route remained parts of US 29 and US 501.
In 1989, US 460 was placed on its current Lynchburg Bypass routing, replacing VA 224. The old route remained part of US 29 (now 29 Bus) and US 501/VA 128.

US 460 moved to Timberlake and freeways 1977 Official

US 460 on all freeways 1989 Official

Lynchburg to Petersburg:
US 460 followed its current route (save the recently altered route at the US 29 interchange) over to Appomattox, except it used SR 800 through Concord and SR 689 through Spout Spring. US 460 used 460 Business through Appomattox (possibly used SR 1004 at first), then US 460 over to Pamplin City, whre it used today's US 460 Business as well.
US 460 followed its current routing east, then used SR 695 approaching Farmville instead of modern US 460. US 460 followed High St to VA 45 then north to 3rd St east out of Farmville, then current US 460 east then dipped south on today's SR 735 through Rice to modern US 460. US 460 followed today's 460 to Burkeville except it used the SR 736 loop. At Burkeville, US 460 used SR 716 Namozine St (partly cutoff from US 360-460 now), then US 360 Business 2nd St.
US 460 used current 460 through Crewe, then at Nottoway CH, it followed US 460 BUsiness through Blackstone. US 460 picked back up current 460 into Dinwiddie County. At Walkers, US 460 followed SR 751 through Poole Siding and Church Road, then back to US 460 before Sutherland. US 460 veered off using VA 226 over to US 1.
Adjustments: In July 1940 (CTB), US 460 was rerouted in Farmville to the current US 460 Business routing on 3rd St all the way through. High St remained part of US 15.

US 460 zig-zags in Farmville early on
1936 Prince Edward County

US 460 via Airline 1933 Norfolk County

VA 287, US 58, and US 460 all swap 1934 Official

About 1942, US 460 was rerouted from Suffolk to Portsmouth - it left Main St Suffolk on today's US 13-58-460 Bus east to mainline 13-58-460. US 460 then followed its current routing to Bowers Hill, Military Hwy and Bainbridge Blvd. US 460 then continued west on Brambleton Ave to end at no route at Granby St. The old route from Suffolk to South Norfolk became VA 337; Princess Anne Rd out to Military Hwy leaving Norfolk became VA 13Y; VA 165 to Diamond Springs Rd became part of US 13; Diamond Springs Rd to US 60 became the other VA 13Y.
By 1954, US 460 was rerouted in Petersburg to used Washington St directly to Crater Rd south.
In 1958, US 460 was rerouted in Norfolk to its current routing to US 60 Ocean View, replacing VA 170 on Granby St.

US 460 ends at Ches Beach 1936 Official

US 460 ends Downtown 1947 Official

US 460 ends at Ocean View 1959 Official

In Feb 1961 (CTB), US 460 was split in Petersburg - EB US 460 had to follow US 301 south to I-95 and use what had been US 460 ALT to get back to Winfield Rd which US 460 WB continued to use.
In 1973, US 460 was given its freeway bypass of Suffolk, leaving behind US 460 Business. AT first it was just US 460 as the freeway wasn't open west of there back to US 58.
About 1976, US 1-460 was placed on one-way splits using Washington and Wythe Sts.

US 460 early Petersburg route 1936 Official

US 460 Petersburg changes 1959 Official

US 460 more changes 1976 Official

In 1990, US 460 was placed on I-85 at Exit 61 up to I-95 then it got off I-95 at the next exit. Here it replaced unsigned US 460 ALT back to US 460 near Ft. Lee. The old route became US 460 Business.
Around 2007, US 460 was rerouted to stay on I-95 south to Wagner Rd, then put on Wagner Rd east to US 460/VA 106. This left behind an extended US 460 Business.
A new US 460 tollway was expected to begin construction in 2014 between I-295 and US 58.  The tollway would be built south of existing US 460. However, despite spending a substantial amount of money, VDOT was not able to get environmental approvals for this endeavor. In 2015 the proposed project was pared down to a new alignment from east of Zuni to teh Suffolk Bypass.
Improvements: The entirety of US 460 was paved upon its designation in July 1933.
The first multilaning of US 460 occurred by 1941, where US 460 was multilaned from Petersburg to Suffolk except for Sussex County.
US 460 was multilaned when moved to Military Hwy around 1942, plus from Magnolia to Bowers HIll.
Sussex County's US 460 was widened by 1947.
In 1949, US 11-460 was multilaned from roughly Elliston to near the current WCL of Salem.
In 1952, US 460 was multilaned on its Campbell Ave run in Lynchburg and also from Christiansburg east a couple miles.
In 1953, US 11-460 was widened from the bottom of Christiansburg Mtn to Elliston.
In 1954, US 460 was multilaned west a couple miles from Bedford.
In 1955, US 460 was widened from US 501 east a couple miles and also the Bedford segment was widened to about Thaxton.
In 1956, US 460 was widened for a mile east out of Pearisburg; the segment east of US 501 was extended halfway to Concord; the Bedford segment was extended around Thaxton and a few more miles west.
In 1957, US 460 was widened from Salem to VA 117.
In 1958, US 460 was multilaned when it was added to Granby St in Norfolk.
In 1959, the US 460 Bedford segment was widened west to just short of Botetourt County.
In 1960 or 1961, US 460 was widened from Suffolk to Magnolia and also on its Brambleton Ave stretch.
In 1963, US 460 was widened from VA 117 to VA 116 and also from 11th Ave to US 11-220 in Roanoke.
In 1964, US 460 was multilaned from Deel to about Jamey.
In 1965, US 460 was multilaned from VA 114 to VA 111; the Bedford segment was widened to Botetourt County; also from a little east of Concord to Appomattox.
In 1966, US 460 was widened from VA 114 north to the SCL Blacksburg ; also from the Blue Ridge Pkwy to Bedford County; also the missing Concord segment was widened; also from US 360 west a couple miles.
In 1967, US 460 was widened from a little east of VA 115 to the Blue Ridge Pkwy.
In 1968, US 460 was multilaned from Jamey to Raven; a segment west of Bluefield was widened; also Appomattox east past Evergreen was widened.
In 1969, US 460 was widened from Cedar Bluff to Claypool Hill; also from the current east end of the Tazewell Bypass to the Bluefield segment; west of Newport to the north end of the Blacksburg Bypass; US 460 was widened from Burkeville to Crewe.
In 1970, US 460 was widened from Raven to Richlands; the Blacksburg Bypass; the Christiansburg Bypass; VA 115 east to previous widening; Evergreen to the east end of Pamplin City Bypass; Sutherland to US 1
In 1971, US 460 was widened from Glen Lyn partway to Rich Creek; VA 61 to the New River; The relocated segment of US 460 from Bedford to Lynchburg; US 301 duplex
In 1972, US 460 was multilaned on the Richlands-Cedar Bluff Bypass; Pamplin City to Prospect; Farmville to Rice; Crewe to Nottoway
In 1973, US 460 was widened from Claypool Hill to Pounding Mill; US 11 to VA 115; Rice to Burkeville; Suffolk Bypass
In 1974, US 460 is shown multilaned from Glen Lyn to VA 61; Prospect partway to Farmville; Ford to Sutherland. The Rice to Burkeville segment was shown as 2-lane on 1974 official.
In 1975, US 460 was widened on the Tazewell Bypass; Pearisburg to near Pembroke; Rice to Burkeville
In 1976, US 460 was widened from Pounding Mill to Tazewell; Pembroke eastward a couple miles; Nottoway-Blackstone Bypass; one-way splits with US 1 in Petersburg
In 1978, The gap on US 460 between Pearisburg and Newport was widened; the west half of the Farmville Bypass; east end of Blackstone Bypass to Wilson
In 1979, the eastern end of the Bluefield Bypass and half the gap between Wilson and Ford were widened.
In 1980, US 460 was widened in the Grundy area; gap west of Pearisburg; Wilson to Ford gap
In 1981, US 460 was multilaned on the Pearisburg Bypass.
In 1988, US 460 was widened across the Elizabeth River down to the VA 168 split.
In 1991, US 460 was multilaned through Petersburg by being added to I-85 and I-95.
In 1994, US 460 was multilaned on the Appomattox Bypass
In 1997 or 1998, US 460 was widened on the eastern half of the Farmville Bypass
In 1999 or 2000, US 460 was multilaned on the western half of the Bluefield Bypass.
In 2002, US 460 was widened from Grundy halfway to Van Sant.
In late 2013, US 460 was multilaned on the new bypass built between Van Sant and Grundy.
In Jan 2015, US 460 was 4-laned between Glenvar and VA 112.
Much of US 460 between Military Hwy and South Norfolk is undivided 4-lane, but VDOT Maps do not show this.
The remaining 2-lane segments of US 460 in Virginia are: Kentucky to Grundy; I-81 to bottom of Christiansburg Mtn (3 lanes); through central Salem; VA 116 to 10th St in Roanoke (3 lanes); inside the corporate limits of Crewe (3 lanes); bits and pieces in the South Norfolk area
Posted:  Fully posted; Erroneously still fully posted with US 19 through Bluefield; the last known cutouts associated with mainline US 460 are on this piece of US 19 - 3 cutouts east of VA 102 as of 2008.
Error VA 460 shields at I-64, Exit 297 since at least 2006.
Multiplexes:  US 58 Bus (1.76 mi)
VA 337 (0.41 mi)
VA 168 (0.40 mi)
VA 166, VA 168 (1.03 mi)
VA 166 (4.40 mi)
US 13 (7.03 mi)
US 13, VA 191 (0.18 mi)
US 13, US 58 (10.68 mi)
US 13, US 58, VA 32 (0.93 mi)
I-95 (3.29 mi)
I-85 (5.24 mi)
VA 49 (1.80 mi)
US 360 (1.68 mi)
US 15 (4.56 mi)
VA 24 (8.62 mi)
US 29 (3.71 mi)
US 29, US 501 (2.36 mi)
US 221, VA 122 (1.44 mi)
US 221 (22.50 mi)
US 220 ALT, US 221 (4.81 mi)
US 11 ALT, US 220 ALT, VA 116 (0.24 mi)
US 11 ALT, VA 116 (2.31 mi)
US 11 ALT (2.84 mi)
US 11 (22.15 mi)
I-81 (1.15 mi)
US 19 (27.47 mi)
VA 67 (1.38 mi)
VA 83 (3.95 mi)
Legislative names:  Governor George C. Peery Highway, Tazewell County (since 3/4/90); Freya Dalton Bridges over VA 67 (since 4/14/98); C. Jefferson Stafford Highway, Bluefield Bypass (since 4/6/96); Andrew S. Rowan Bridge (3/5/40 designation predates US 460); Mary Porter Bridge over East River (3/5/40 designation predates US 460);Anderson E. Shumate Memorial Bridge over New River (3/2/42 designation predates US 460); Madison E. Marye Highway, between Blacksburg and Christiansburg US 460 Business routes (since 3/16/03); Terry L. Griffith Memorial Highway, in Town of Christiansburg (since 3/13/01); 116th Infantry Regiment Memorial Highway, from Roanoke to Bedford (since 3/2/97); Colonial Trail, from Roanoke to Bedford and from Lynchburg to Petersburg, not including bypasses (3/24/30 designation predates US 460); Charles T Moses Memorial Highway, from Appomattox to Lynchburg (since 2/23/66)
Other names:  Virginia Ave (Glen Lyn, Rich Creek, Narrows); Roanoke St (Montgomery County east of I-81); W. Main St (Roanoke County west of Salem); Main St/E. Main St (Salem); Melrose Ave/Orange Ave (Roanoke); Challenger Ave (Roanoke County east of Roanoke); Lynchburg-Salem Tpk (Bedford County except Bedford Bypass); Lynchburg Hwy (Campbell County and Lynchburg); Richmond Hwy (Appomattox County); Virginia Ave (Crewe); Cox Rd (SR 627 to VA 226); Airport St (VA 226 to I-85); County Dr (VA 106 to Sussex County); Pruden Blvd (Suffolk west of Bypass); Suffolk Bypass (guess); Military Hwy (Suffolk Bypass to VA 166 except in Bowers Hill); Bainbridge Blvd/Poindexter St/22nd St (Chesapeake); Wilson Rd/Campostella Rd/Brambleton Ave/St Pauls Blvd/Monticello Ave/Granby St (Norfolk)
Scenic Byway:  US 19 duplex except Tazewell Bypass (9/15/99)
Comments: US 460 is a major artery throughout Virginia. As such, US 460 would probably make more sense to be routed with I-81 around Salem and Roanoke and using 220 ALT to get back down to present US 460.
Norfolk has now fully signed US 460 along Church St between Monticello Ave and Brambleton Ave, a process that began ca. 2004.  However, official VDOT documents still have US 460 as following Monticello Ave.

US 460 ALT initial downtown routing 1963 Gen Draft

US 460 ALT current downtown routing 1989 Official

US 460 ALT was moved onto I-264 from Portsmouth Blvd. through Portsmouth in March 1968 (CTB). Portsmouth Blvd remained part of VA 337 while the remainder is city streets.

US 460 ALT initial Portsmouth routing 1961 Official

US 460 ALT current Portsmouth routing 1989 Official

US 460 ALT was not explicitly labeled on Officials until 1955.
Improvements:  Paved upon inception; Multilane on its VA 337 and I-264 multiplexes, plus Downtown Norfolk.
Posted:  Fully posted from Bowers Hill to I-264. The last shield EB directs you onto I-264. In 1993 there was 1 shield on Monticello Ave at City Hall Ave but appears to be gone now. By February 2013, a new shield was installed on Brambleton Ave at St. Paul's Blvd.
Multiplexes:  US 58 (3.79 mi)
VA 337 (0.25 mi)
I-264 (4.02 mi)
I-264, VA 337 (0.41 mi)
Legislative names:  A.L. Philpott Memorial Highway, US 58 duplex (since 3/3/92)
Other names:  Airline Blvd (US 58 duplex); Portsmouth Blvd (VA 337 duplex); St. Pauls Blvd/Monticello Ave/City Hall Ave (Norfolk)
Scenic Byway:  no segments
Comment: US 460 ALT is much more direct (4.15 miles shorter) from Bowers Hill to Norfolk than mainline US 460.