US 521 Business
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From: Kershaw, SC
To:  Kershaw, SC
Total Length:  1.5 miles    
ROUTE LOG
US 521, US 601, US 601 Bus Begin: 0 - 0
SC 341: 0.5 - 0.5
US 601, US 601 Bus END: 0.3 - 0.8
US 521: 0.7 - 1.5
 Creation: Created between 1947-50 as the 1st US 521 Business when US 521 was moved to replace US 521 ALT two blocks west.
Adjustments: None
Comments: US 521 Business uses Hampton St through Kershaw
SC didn't send an application for this until 2004!

1942 Lancaster County
US 521 through Kershaw
1942 Lancaster County
1950 Lancaster County
US 521 Business through Kershaw
1950 Lancaster County


From: south of Lancaster, SC
To:  Lancaster, SC
Total Length:  4.0 miles    
ROUTE LOG
US 521: 0 - 0
SC 200 SB: 1.7 - 1.7
SC 903: 0.6 - 2.3
SC 9 Bus EB: 0.1 - 2.4
SC 9 Bus WB: 0.3 - 2.7
SC 200 NB: 1.0 - 3.7
US 521, SC 9: 0.3 - 4.0
 Creation: Approved in October 1965 by AAASHO and opened about 1967 as the 2nd US 521 Business when US 521 was placed on its Lancaster bypass
Adjustments: In August 1992 (SCDOT), US 521 Business was rerouted to use Market St from Main St below SC 200 to Barr St west back to Main St. The bypassed portion of Main St is now S-26-2.
Comments: US 521 Business still had cutouts on it in the early 1990s.

1963 Lancaster County
US 521 through Lancaster
1963 Lancaster County
1967 Lancaster County
US 521 Business through Lancaster
1967 Lancaster County
2005 Lancaster County
US 521 Business through Lancaster
2005 Lancaster County


From: east of Andrews, SC
To:  Andrews, SC
Total Length:  3.1 miles    
ROUTE LOG
US 521: 0 - 0
SC 41 Bus: 2.1 - 2.1
US 521, SC 41: 1.0 - 3.1
 Creation: Appeared in 2005 as the 3rd US 521 Business when US 521 was placed on its Andrews bypass
Adjustments: None
Comments: US 521 Business uses Main St

1996 Official
US 521 through Andrews
1996 Official
2006 Official
US 521 Bypasses Andrews
2006 Official

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Page last modified 19 February 2026