US 421 Business
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Photo: US 421 Business in N. Wilkesboro NC (GMSV, June 2018)
US 421 Bus

From: Gate City, VA
To:  Gate City, VA
Total Length:  2.7 miles    
ROUTE LOG
US 23, US 23 Bus Begin, US 58, US 58 Bus Begin, US 421: 0 - 0
VA 71: 0.8 - 0.8
US 23, US 23 Bus END, US 58, US 58 Bus END, US 421: 1.9 - 2.7
Creation: Created October 1966 (CTB) as the 2nd US 421 Business when US 421 was placed on its southern bypass of Gate City VA.
Adjustments: None
Comments: US 421 Business uses Kane St and Jackson St through Gate City.

1993 Scott County
US 421 Business through Gate City
1993 Scott County

From: near Call, NC
To:  Wilkesboro, NC
Total Length:  4.9 miles    
ROUTE LOG
US 421, NC 115 SB: 0 - 0
NC 18 NB, NC 115 END, NC 268 EB: 1.7 - 1.7
NC 18 SB, NC 268 WB: 1.1 - 2.8
US 421, NC 16: 2.1 - 4.9
Creation: Appeared in November 1969 (NCDOT) as the 3rd US 421 Business. This was arenumbering of US 421 south of Old US 421 Rd; addition to NC 115; addition to NC 18-268 into downtown N. Wilkesboro; replaced US 421 ALT back out to US 421.
Adjustments: None
Comments: US 421 Business uses Statesville Rd; B St/6th St/B St through North Wilkesboro.
Interestingly, US 421 Business has a concurrency with NC 18-268, but does not share in the split alignment of NC 18-268. US 421 Business in both directions follows the NC 18 SB/268 WB path.

1962 Wilkes County
NC 115 and US 421-A through N. Wilkesboro
1962 Wilkes County
1972 Wilkes County
US 421 Business appears
1972 Wilkes County


From: Richmond, KY
To:  Richmond, KY
Total Length:  3.7 miles    
ROUTE LOG
US 25, US 25 Bus Begin, US 421. KY 876: 0 - 0
KY 52 EB: 1.0 - 1.0
KY 388: 0.6 - 3.6
KY 52 WB: 0.2 - 1.8
KY 169: 0.3 - 2.1
KY 3087: 1.3 - 3.4
US 25, US 25 Bus END, US 421: 0.3 - 3.7
Creation: Appeared in June 1999 (KYTC) as the 5th US 421 Business when US 421 was placed on its Richmond KY bypass. Note that the segment north of KY 3087 was new construction.
Adjustments: None
Comments: US 421 Business uses Bighill Ave and Main St through Richmond.
So far I have not found a single map that shows this as US 421 Business (shows US 25 Bus only), but it is definitely posted as both.

2002 Official
US 25-421 Business through Richmond
2002 Official
2023 GMSV
US 421 Business in Richmond
June 2023 GMSV


From: Sanford, NC
To:  Cumnock, NC
Total Length:  9.8 miles    
ROUTE LOG
US 421, NC 87 Byp: 0 - 0
NC 87 SB: 0.7 - 0.7
NC 42 EB, NC 78: 1.1 - 1.8
US 1 Bus, NC 42 WB: 2.6 - 4.4
US 1, US 15, US 501, NC 87 NB: 1.3 - 5.7
US 421: 4.1 - 9.8
Creation: Appeared in February 2015 as the 6th US 421 Business when US 421 was placed on its Sanford NC bypass.
Adjustments: None
Comments: US 421 Business uses Horner Blvd through Sanford, plus Boone Trail.
2017-18 Official

2017-18 Official
US 421 Business  decommissioned segments
Previous US 421 Business's:

Final ROUTE LOG (#1)
US 25, US 25 Bus Begin, US 421, KY 4: 0 - 0
US 60 Bus EB: 2.6 - 2.6
US 27, US 60 Bus WB, US 68: 0.7 - 3.3
US 25 Bus NB: 0.5 - 3.8
US 60, US 421, KY 4: 1.8 - 5.6


Final ROUTE LOG (#3)
US 17, US 17 Bus Begin, US 74, US 76, US 421: 0 - 0
US 17 Bus NB: 1.0 - 1.0
US 117 NB, NC 133 NB: 1.1 - 2.1
US 117 END, US 421, NC 133 SB: 0.6 - 2.7
US 421 Business #1: Created about 1961, US 421 was placed on an eastern bypass of Lexington KY.
Between 1969-71, US 421 Business was given one-way splits through downtown, with NB using the original Main St route and SB using Vine St.
US 421 Business reverted back to US 421 about 2002.

1966 Official
US 421 Business through Lexington
1966 Official
2002 Official
US 421 Business reverts back to US 421
2002 Official

US 421 Business #3: Created Aug 1971 (NCDOT) as an addition to US 117-NC 133 across the NE Cape Fear River and an upgrade to SR 1627 down 3rd St to 16th St where it connected back up with US 421. This had been mainline US 421 up until Sept 1969 (NCDOT).
In 1975, US 421 Business was decommissioned, leaving behind US 117-NC 133 across the river and US 17 Business (since moved) on 3rd St south of Market St.

1971 Official
3rd St unnumbered
1971 Official
1972-73 Official
US 421 Business appears
1972-73 Official
1975 Official
US 421 Business disappears
1975 Official



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Page last modified 19 April 2026