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From:
     
Gate City, VA
To:
     
Gate City, VA
Total Length: 2.7 miles
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ROUTE LOG
US 23, US 23 Bus Begin, US 58, US 58 Bus Begin, US 421: 0 - 0
VA 71: 0.8 - 0.8
US 23, US 23 Bus END, US 58, US 58 Bus END, US 421: 1.9 - 2.7
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Creation: Created October 1966 (CTB) as the 2nd US 421 Business when US 421 was placed on its southern bypass of Gate City VA.
Adjustments: None
Comments: US 421 Business uses Kane St and Jackson St through Gate City.
US 421 Business through Gate City
1993 Scott County
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From:
  
near Call, NC
To:
  
Wilkesboro, NC
Total Length: 4.9 miles
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ROUTE LOG
US 421, NC 115 SB: 0 - 0
NC 18 NB, NC 115 END, NC 268 EB: 1.7 - 1.7
NC 18 SB, NC 268 WB: 1.1 - 2.8
US 421, NC 16: 2.1 - 4.9
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Creation: Appeared in November 1969 (NCDOT) as the 3rd US 421 Business. This was arenumbering of US 421 south of Old US 421 Rd; addition to NC 115; addition to NC 18-268 into downtown N. Wilkesboro; replaced US 421 ALT back out to US 421.
Adjustments: None
Comments: US 421 Business uses Statesville Rd; B St/6th St/B St through North Wilkesboro.
Interestingly, US 421 Business has a concurrency with NC 18-268, but does not share in the split alignment of NC 18-268. US 421 Business in both directions follows the NC 18 SB/268 WB path.
NC 115 and US 421-A through N. Wilkesboro
1962 Wilkes County
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US 421 Business appears
1972 Wilkes County
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From:
  
Sanford, NC
To:
 
Cumnock, NC
Total Length: 9.8 miles
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ROUTE LOG
US 421, NC 87 Byp: 0 - 0
NC 87 SB: 0.7 - 0.7
NC 42 EB, NC 78: 1.1 - 1.8
US 1 Bus, NC 42 WB: 2.6 - 4.4
US 1, US 15, US 501, NC 87 NB: 1.3 - 5.7
US 421: 4.1 - 9.8
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Creation: Appeared in February 2015 as the 6th US 421 Business when US 421 was placed on its Sanford NC bypass.
Adjustments: None
Comments: US 421 Business uses Horner Blvd through Sanford, plus Boone Trail.
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2017-18 Official
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US 421 Business decommissioned segments |
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Previous US 421 Business's:
Final ROUTE LOG (#1)
US 25, US 25 Bus Begin, US 421, KY 4: 0 - 0
US 60 Bus EB: 2.6 - 2.6
US 27, US 60 Bus WB, US 68: 0.7 - 3.3
US 25 Bus NB: 0.5 - 3.8
US 60, US 421, KY 4: 1.8 - 5.6
Final ROUTE LOG (#3)
US 17, US 17 Bus Begin, US 74, US 76, US 421: 0 - 0
US 17 Bus NB: 1.0 - 1.0
US 117 NB, NC 133 NB: 1.1 - 2.1
US 117 END, US 421, NC 133 SB: 0.6 - 2.7
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US 421 Business #1: Created about 1961, US 421 was placed on an eastern bypass of Lexington KY.
Between 1969-71, US 421 Business was given one-way splits through downtown, with NB using the original Main St route and SB using Vine St.
US 421 Business reverted back to US 421 about 2002.
US 421 Business through Lexington
1966 Official
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US 421 Business reverts back to US 421
2002 Official
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US 421 Business #3: Created Aug 1971 (NCDOT) as an addition to US 117-NC 133 across the NE Cape Fear River and an upgrade to SR 1627 down 3rd St to 16th St where it connected back up with US 421. This had been mainline US 421 up until Sept 1969 (NCDOT).
In 1975, US 421 Business was decommissioned, leaving behind US 117-NC 133 across the river and US 17 Business (since moved) on 3rd St south of Market St.
3rd St unnumbered
1971 Official
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US 421 Business appears
1972-73 Official
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US 421 Business disappears
1975 Official
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Previous: US 420 |
Next: US 422
US 421 | US 421 ALT
US 21 | US 121 | US 221 | US 321 | US 521
US 421 at US Ends.com
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Page last modified
19 April 2026
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