US 378 Business
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US 378

US 378 at US Ends.com

Photo: West beginning of US 378 Business for Lake City (SCDOH, circa 1960) 		US 378

From: Lake City, SC
To:  Lake City, SC
Total Length:  4.4 miles    
ROUTE LOG
US 378, SC 341 NB: 0 - 0
US 52: 2.0 - 2.0
SC 341 SB: 0.6 - 2.6
US 378: 1.8 - 4.4
 Creation: Appeared in 1957 as the 1st US 378 Business, when US 378 was given its northern bypass of Lake City SC.
Adjustments: None
Comments: Main St and Church St through town.

1953 Florence County
US 378 through Lake City
1953 Florence County
1963 Florence County
US 378 bypasses Lake City
1963 Florence County

Previous US 378 Business's:

LAST ROUTE LOG (378 Bus #2)
US 76, US 76 Bus Begin, US 378: 0 - 0
US 521 NB: 0.2 - 0.2
US 15 CONN: 0.8 - 1.0
US 401: 2.2 - 3.2
SC 763: 0.3 - 3.5
US 15: 0.5 - 4.0
US 76 Bus EB: 0.5 - 4.5
US 378: 2.1 - 6.6
US 378 Bus #2: Appeared November 1958 (SCDOT), when US 378 was given its northern bypass of Sumter.
In November 1973 (AASHTO), US 378 Business was decommissioned. Most of the route remains US 76 Business except the easternmost 2 miles became an extended SC 763.

1953 Sumter County
US 378 through Sumter
1953 Sumter County
1963 Sumter County
US 378 Business through Sumter
1963 Sumter County

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US 378 at US Ends.com

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Page last modified 4 July 2026