U.S. Highway 221
| 
 | Southern Terminus | Northern Terminus | 
| Virginia | NC/VA State Line south of Wytheville, VA | At US 29/BUS US 460/BUS US 501 in Lynchburg, VA | 
| Nationally | At US 19/US 98 in Perry, FL | At US 29/BUS US 460/BUS US 501 in Lynchburg, VA | 
Southern Terminus
| US 21-221 southbound at the North Carolina State Line. Photo by Mapmikey, taken April 13, 2007. | |
| First US 21-221 southbound reassurance in North Carolina. Photo by Mapmikey, taken April 13, 2007. | |
| US 21-221 northbound entering Virginia. Photo by Mapmikey, taken April 13, 2007. | |
| US 21-221 northbound reassurance at the state line. Photo by Mapmikey, taken April 13, 2007. | 
Northern Terminus
| US 221 begins at a cloverleaf with then-US 29 (now a BUSINESS route) while multiplexed with BUSINESS US 460 and BUSINESS US 501. Photo by Andrew Snyder, taken March 9, 2005. | |
| Here is the same scene after the conversion of the freeway to US 29 Business. Photo by Mapmikey, taken January 30, 2006. | |
| This is the first reassurance assembly once on US 221. Photo by Mapmikey, taken January 30, 2006. | |
| Advance signage on US 221 northbound at its end with US 29 Business. Photo by Mapmikey, taken July 22, 2006. | |
| At the actual interchange. Photo by Mapmikey, taken July 22, 2006. | 
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Back to US 221 listing
Last Updated: May 5, 2007
(C) 2007-2005, Adam Froehlig, Mike Roberson